Southern Squash Casserole is a beloved Southern comfort dish that effortlessly combines the creamy richness of cheese with tender yellow squash. This casserole features layers of sautéed squash and onions mixed with sour cream, cheddar, and Parmesan, all topped with a crunchy layer of buttered crackers. It’s perfect for any occasion, from family dinners to potlucks, and even those who usually shy away from squash will find themselves craving seconds. Easy to prepare and packed with flavor, this dish is not only delicious but also makes excellent leftovers.